From
https://jonathanweisberg.org/vip/multiple-conditions.html#multiple-conditions
Every time I think I know what's going on, suddenly there's another layer of complications.
From
https://jonathanweisberg.org/vip/multiple-conditions.html#multiple-conditions
https://www.qeios.com/read/QIH0Q1
When to Adjust Alpha During Multiple Testing - Article (v1) by Mark Rubin | Qeios
proc sort data=have(keep=key1 key2); by key1 key2; run;data want; do count=1 by 1 until(last.key2); set have; by key1 key2; end; run;
In mixed models, if use MLE, we have to assume that fixed effects are known, rather than being estimated from the data. If we use REML (residual maximum likelihood) it will automatically adjust for the degree of freedom corresponding to estimated fixed effects. This is the key difference between MLE and REML in mixed models, however, the difference will be very small when the sample size is big.